Thrombin inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 409/12 (2006.01) C07D 403/12 (2006.01) C07D 407/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2355281

The present invention relates to thrombin inhibitors of formula (I), wherein A, B, C, D, E, F and n have the meaning given in the description, that are useful as anticoagulants. In particular, this invention relates to peptide derivatives having high antithrombotic activity and high oral bioavailability.

La présente invention concerne des inhibiteurs de thrombine selon la formule (I). Dans cette dernière, A, B, C, D, E, F et n ont la signification donnée dans le descriptif et présentent un grand intérêt comme anticoagulants. En particulier, la présente invention concerne des dérivés de peptides présentant une grande activité antithrombotique et une biodisponibilité orale élevée.

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