Thrombin inhibitors

Details Thrombin inhibitors Thrombin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) C07D 257/04 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2436176

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure Formula (I): wherein u is CH or N; Q is 1)-N(R25)CH(R30)- wherein the nitrogen atom is attached to R1, and R25 and R30 are independently selected from the group consisting of hydrogen, C3-6cycloalkyl, and C1-6alkyl, or 2) wherein the nitrogen atom is attached to R1, and m is 0, 1, or 2.

Les composés de cette invention conviennent pour inhiber une thrombine et des occlusions thrombotiques associées. Ils sont représentés par la formule structurelle suivante (I). Dans cette formule u est CH ou N, Q est 1)-N(R?25¿)CH(R?30¿)- l'atome d'azote étant attaché à R?1¿, R?25¿ et R?30¿ sont indépendamment sélectionnés dans le groupe constitué de hydrogène, C¿3-6?cycloalkyle, et C¿1-6?alkyle, ou 2) l'atome d'azote étant attaché à R?1¿, et m est 0, 1, ou 2.

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