Thrombin inhibitors comprising an aminoisoquinoline group

Details Thrombin inhibitors comprising an aminoisoquinoline group Thrombin inhibitors comprising an aminoisoquinoline group

C - Chemistry, Metallurgy

07

D

C07D 217/22 (2006.01) A61K 31/4725 (2006.01) C07D 401/12 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2413035

The invention relates to a compound having the formula (I) wherein R1 is cyclopentyl, cyclohexil or branched (3-4C) alkyl; R2 is cyclohexyl or phenyl; R3 is H or methyl; and A is an unsubstituted saturated 4, 5 or 6-membered ring; or a pharmaceutically acceptable salt thereof. The compounds of the invention have anticoagulant activity and can be used in treating or preventing thrombin-mediated and thrombin-associated diseases.

L'invention concerne un composé de formule (I) dans laquelle R¿1? est cyclopentyle, cyclohexyle ou (3-4C) alkyle ramifié ; R¿2? est cyclohexyle ou phényle ; R¿3? est H ou méthyle ; et A est un noyau saturé non substitué à 4, 5 ou 6 éléments ; ou un sel pharmaceutiquement acceptable dudit composé. Les composés de ladite invention ont une activité anticoagulante et peuvent être utilisés dans le traitement ou la prévention de maladies induites par la thrombine et associées à cette dernière.

Affiliated with

Also associated with

Rating

Thrombin inhibitors comprising an aminoisoquinoline group does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thrombin inhibitors comprising an aminoisoquinoline group, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thrombin inhibitors comprising an aminoisoquinoline group will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1991734