Thrombin or factor xa inhibitors

Details Thrombin or factor xa inhibitors Thrombin or factor xa inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/50 (2006.01) C07D 207/09 (2006.01) C07D 207/273 (2006.01) C07D 209/00 (2006.01) C07D 213/64 (2006.01) C07D 213/73 (2006.01) C07D 241/00 (2006.01) C07D 241/18 (2006.01) C07D 295/192 (2006.01) C07D 295/26 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01) C07D 517/04 (2006.01)

Patent

CA 2413241

This invention relates generally to heteroaryl-phenyl substituted compounds that are inhibitors of trypsin-like serine protease enzymes, especially factor Xa or thrombin, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.

Cette invention se rapporte d'une façon générale à des composés à substitution hétéroaryle-phényle, qui constituent des inhibiteurs des enzymes sérine-protéases de type trypsine, en particulier le facteur Xa ou la thrombine, à des compositions pharmaceutiques contenant ces composés, et à des procédés d'utilisation de ceux-ci comme agents anticoagulants dans le traitement et la prévention des affections thromboemboliques.

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