Thrombin preparation and products and fibrin sealant methods...

Details Thrombin preparation and products and fibrin sealant methods... Thrombin preparation and products and fibrin sealant methods...

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61K 35/16 (2006.01) A61L 24/10 (2006.01) C07K 14/745 (2006.01)

Patent

CA 2322741

The invention employs liposomes having an outer surface presenting both acidic and basic polar groups, for example phosphatidyl for rapid, high yield generation of thrombin from prothrombin-containing material. The source material for the prothrombin can be the subject to be treated with the product thrombin, providing an autologous thrombin product. Also, a fibrinogen component can be generated from the same blood sample, yielding a fully autologous fibrin sealant when activated with thrombin product from the same blood sample.

L'invention concerne l'utilisation de liposomes présentant une surface extérieure comprenant à la fois des groupements polaires acides et basiques, par exemple des liposomes de phosphatidyle, de façon à obtenir une production de thrombine rapide et à rendement élevé, à partir d'un matière contenant de la prothrombine. La matière fournissant la prothrombine peut être traitée avec la thrombine obtenue, donnant ainsi un produit autologue à base de thrombine. En outre, un composant fibrinogène peut être produit à partir du même échantillon sanguin, donnant ainsi, lorsqu'il est activé avec un produit à base de thrombine issu du même échantillon sanguin, un matériau d'obturation à base de fibrine entièrement autologue.

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