Thrombin receptor antagonists as prophylaxis to...

Details Thrombin receptor antagonists as prophylaxis to... Thrombin receptor antagonists as prophylaxis to...

A - Human Necessities

61

K

A61K 31/443 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2634216

Disclosed herein are methods of preventing, inhibiting, or ameliorating complications associated with cardiopulmonary bypass surgery by the use of a thrombin receptor antagonist compound. Among the thrombin receptor antagonis compounds useful in these methods are those of Formulas (I), (II) and (III), described herein. Examples of such thrombin receptor antagonists include formulae (I), (II) and (III).

La présente invention concerne des procédés de prévention, d'inhibition ou d'amélioration de complications associées à une dérivation cardio-pulmonaire par l'utilisation d'un composé d'antagoniste de récepteur de thrombine. Citons parmi les composés d'antagoniste de récepteur de thrombine utiles dans ces procédés, ceux des Formules I et II, décrits ici. Des exemples de tels antagonistes de récepteurs de thrombine incluent des Formules (I), (II) et (III).

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