A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/36 (2006.01) A61K 38/37 (2006.01) A61K 38/57 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 1/10 (2006.01) C07K 14/475 (2006.01) C07K 14/705 (2006.01) C07K 14/745 (2006.01) C07K 14/755 (2006.01) C07K 14/81 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 9/50 (2006.01) C12N 9/68 (2006.01) C12N 15/57 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2318434
Thrombosis-initiating chimeric polypeptides and conjugates, where Figure 1 portrays one of the disclosed examples of the latter, are provided, as well as compositions comprising same and nucleic acid constructs encoding same. At least one component of a chimera or a conjugate is specific for one or more external features of the vascular endothelium of vessels nourishing a tumor and at least one thrombotic component is substantially inactive when not associated with said tumor vascular endothelium, permitting specific destruction of cancer cells of solid tumors in an animal.
L'invention concerne des polypeptides et des conjugués chimères initiateurs de thrombsose, un exemple de ces polypeptides et conjugués étant donné dans la Figure 1. L'invention concerne également des compositions renfermant ces polypeptides et ces conjugués, et des produits de recombinaison d'acide nucléique codant ces derniers. Au moins un constituant d'une chimère ou d'un conjugué est spécifique à une ou plusieurs caractéristiques externes de l'endothélium vasculaire des vaisseaux entretenant une tumeur, et au moins un constituant thrombosant est sensiblement inactif si non associé à cet endothélium vasculaire tumoral, ce qui permet une destruction ciblée des tumeurs solides chez un animal.
Dickinson Craig D.
Houston L.l.
Gowling Lafleur Henderson Llp
Nuvas Llc
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