Thrombolytic agents with modified kringle domains

Details Thrombolytic agents with modified kringle domains Thrombolytic agents with modified kringle domains

C - Chemistry, Metallurgy

07

H

195/39.1, 195/1.

C07H 21/04 (2006.01) C12N 9/64 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2001343

ABSTRACT THROMBOLYTIC AGENTS WITH MODIFIED KRINGLE DOMAINS This invention is to analogs of thrombolytic agents having a modified kringle domain. More specifically this invention is directed to TPA type compounds wherein modifications in the kringle 1 and kringle 2 domains occur. This invention is also directed to analogs with one or more changes in the kringle domain of urokinase- type compounds. The compounds o f this invention are pharmaceutically useful having particular use in the same manner as TPA and urokinase.

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