Thrombomodulin derivatives and conjugates

Details Thrombomodulin derivatives and conjugates Thrombomodulin derivatives and conjugates

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01)

Patent

CA 2598394

The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured blood vessels under physiologic conditions in vivo. Compositions and methods are disclosed relating to thrombomodulin derivatives and conjugates, including methods for site-specific pegylation and compositions of a truncated thrombomodulin derivative.

La protéine transmembranaire humaine thrombomoduline (TM) en tant que régulateur critique de la voie C protéique représente un mécanisme anticoagulant important actif dans les vaisseaux sanguins normaux et détériorés dans les conditions physiologiques in vivo. On a prévu des compositions et des procédés associés aux dérivés et conjugués de thrombomoduline, et notamment des procédés de pégylation spécifiques de site et des compositions à base d'un dérivé de thrombomoduline tronquée.

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