Thrombopoietic activity of tyrosyl-trna synthetase polypeptides

Details Thrombopoietic activity of tyrosyl-trna synthetase polypeptides Thrombopoietic activity of tyrosyl-trna synthetase polypeptides

A - Human Necessities

61

K

A61K 38/53 (2006.01)

Patent

CA 2727622

Thrombopoietic compositions are provided comprising tyrosyl tRNA synthetase polypeptides, including trunca-tions and/or variants thereof Also provided are methods of using such compositions in the treatment of conditions that benefit from increased thrombopoiesis, such as thrombocytopenia.

L'invention porte sur des compositions thrombopoïétiques comprenant des polypeptides de tyrosyl-ARNt synthétase, comprenant des troncations et/ou des variants de ceux-ci. L'invention porte également sur des procédés d'utilisation de telles compositions dans le traitement d'affections qui bénéficient d'une thrombopoïèse accrue, telle qu'une thrombocytopénie.

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