C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/46 (2006.01) A61K 31/192 (2006.01) A61K 31/4152 (2006.01) A61K 31/454 (2006.01) A61K 31/56 (2006.01) A61K 31/573 (2006.01) A61K 38/18 (2006.01) A61K 38/20 (2006.01) A61K 45/06 (2006.01) A61P 7/00 (2006.01) C07C 61/39 (2006.01) C07D 211/94 (2006.01) C07D 295/185 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2670345
The invention relates to compounds and their use in the treatment of thrombocytopenia resulting from diseases or conditions such as immune thrombocytopenic purpura, cancer chemotherapy, surgery, bone marrow or stem cell transplantation, radiation injury or treatment, chronic viral infection, and pancytopenia. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods for treating such diseases or conditions in a mammal, including a human, by administering to such mammal an effective amount of a selected thrombopoietin receptor agonist.
La présente invention concerne des composés et leur utilisation dans le traitement de la thrombocytopénie, résultant d'états et de maladies tels que la purpura thrombopénique immune, de la chimiothérapie contre le cancer, de la chirurgie, de la transplantation de moelle osseuse ou de cellules souches, du mal des rayons ou des traitements par radiation, des infections virales chroniques, et de la pancytopénie. L'invention concerne en outre des compositions pharmaceutiques contenant les composés et les compositions de l'invention. L'invention concerne enfin des procédés de traitement de ces maladies et de ces états chez un mammifère, incluant l'Homme, par l'administration à un tel mammifère d'une quantité efficace d'un agoniste de récepteur de thrombopoïétine choisi.
Punnonen Juha
Spencer Jeffrey R.
Smart & Biggar
Stategics Inc.
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