C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/14 (2006.01) A61K 31/277 (2006.01) A61K 31/4402 (2006.01) A61K 31/4409 (2006.01) A61K 31/4453 (2006.01) A61P 7/00 (2006.01) A61P 7/04 (2006.01) A61P 7/06 (2006.01) A61P 9/08 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07C 255/32 (2006.01) C07D 211/14 (2006.01) C12P 13/00 (2006.01)
Patent
CA 2495184
A medicine for the prevention of, treatments for, and alleviation of diseases in which thrombopoetin receptor activation is effective. It is a thrombopoetin receptor activator represented by the formula (1): (1) wherein R1 and R3 each independently means hydrogen, SO3H, C1-6 alkyl, C1-6 alkylcarbonyl, or C6-18 arylcarbonyl (the C1-6 alkyl, C1-6 alkylcarbonyl, and C6-18 arylcarbonyl may be optionally substituted by halogeno, hydroxy, C2-6 alkenyl, C1-6 alkoxy, C1- 6 alkoxycarbonyl, C6-18 aryl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3- furanyl, 2-thienyl, 3-thienyl, or NR9R10); and R2, R4, and Ra each independently means hydrogen, hydroxy, or C1-6 alkoxy.
L'invention concerne un médicament utilisé dans la prévention, le traitement ou le soulagement de maladies dans lesquelles l'activation du récepteur de la thrombopoïétine est efficace. L'activateur du récepteur de la thrombopoïétine est représenté par la formule (1) dans laquelle R?1¿ et R?3¿ sont chacun indépendamment hydrogène, alkyle SO¿3?H, alkyle C¿1-6?, alkylcarbonyle C¿1-6?, ou arylcarbonyle C¿6-18 ?(l'alkyle C¿1-6?, l'alkylcarbonyle C¿1-6?, et l'arylcarbonyle C¿6-18?peuvent être éventuellement substitués par halogéno, hydroxy, alcényle C¿2-6?, alkoxy C¿1-6?, alkoxycarbonyle C¿1-6?, aryle C¿6-18?, 2-pyridyle, 3-pyridyle, 4-pyridyle, 2-furanyle, 3-furanyle, 2-thiényle, 3-thyényle ou NR?9¿R?10¿) ; et R?2¿, R?4¿ et R?a¿ sont chacun indépendamment hydrogène, hydroxy, ou alkoxy C¿1-6?.
Ishiwata Norihisa
Kamiya Hisao
Miyaji Katsuaki
Nakamura Takanori
Nishino Taito
Nissan Chemical Industries Ltd.
Smart & Biggar
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