Thromboresistant coating for defoaming applications

Details Thromboresistant coating for defoaming applications Thromboresistant coating for defoaming applications

A - Human Necessities

61

L

A61L 33/00 (2006.01) B05D 1/12 (2006.01)

Patent

CA 2109960

16 ABSTRACT A composition for coating medical blood contacting surfaces comprises a mixture of an anticoagulant and a defoaming agent. The coating composition is applied by either dipping the device into a solution containing the mixture or by spraying the mixture onto the surface. Alternatively, the surface can be sequentially dip coated and/or sprayed with the individual components. In a preferred embodiment, the anticoagulant is a quaternary ammonium complex of heparin, preferably stearyldimethylbenzyl ammonium heparin, and the antifoaming agent is a mixture of polydimethylsiloxane and silicone dioxide.

Une composition utilisée pour recouvrir les surfaces d'instruments médicaux mises en contact avec le sang comprend un mélange composé d'un anticoagulant et d'un agent antimousse. La composition de revêtement est appliquée soit par immersion du dispositif concerné dans une solution contenant ledit mélange soit par vaporisation desdits mélanges sur la surface. Selon un autre procédé, la surface peut être consécutivement recouverte par immersion et/ou par vaporisation avec les composants individuels. Dans un mode préféré de réalisation, l'anticoagulant est un complexe ammonium quaternaire d'héparine, de préférence un complexe stéaryldiméthylbenzyle-ammonium-héparine, et l'agent antimousse est un mélange de polydiméthylsiloxane et de dioxyde de silicone.

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