Thrombus/thrombogenesis inhibitors

A - Human Necessities – 61 – K

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Details

A61K 31/138 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2460777

Thrombus/thrombogenesis inhibitors comprising as the active ingredient aminoalkoxybibenzyls represented by the following general formula (1), pharmaceutically acceptable salts thereof or solvates of the same: (1) wherein R1, R2 and R3 represent each hydrogen, etc.; R4 represents -N(R5)(R6); and m is an integer of from 0 to 5. The above drugs are particularly efficacious for inhibiting thrombus/thrombogenesis in ischemic cerebrovascular failures selected from transient cerebral ischemic attack and cerebral infarction.

L'invention concerne des inhibiteurs de thrombus/thrombogenèse comprenant comme ingrédient actif des aminoalcoxy dibenzyles représentés par la formule générale suivante (I), des sels pharmaceutiquement acceptables ou des solvates de ceux-ci. R?1¿, R?2¿ et R?3¿ représentent chacun hydrogène, etc.; R?4¿ représente N (R?5¿) (R?6¿); et m est un nombre entier situé entre 0 et 5. Les médicaments précités sont particulièrement efficaces en matière d'inhibition de thrombus/thrombogenèse lors d'insuffisances ischémiques cérébrovasculaires, notamment des crises cérébrales ischémiques transitoires et des infarctus cérébraux.

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