Thymidine kinase deletion mutants of bovine herpesvirus-1,...

Details Thymidine kinase deletion mutants of bovine herpesvirus-1,... Thymidine kinase deletion mutants of bovine herpesvirus-1,...

C - Chemistry, Metallurgy

12

N

195/1.26

C12N 15/00 (2006.01) A61K 39/245 (2006.01) C12N 7/00 (2006.01)

Patent

CA 1280986

THYMIDINE KINASE DELETION MUTANTS OF BOVINE HERPESVIRUS-1, VACCINES AGAINST INFECTIOUS BOVINE RHINOTRACHEITIS CONTAINING SAME AND METHODS FOR THE PRODUCTION AND USE OF SAME ABSTRACT OF THE DISCLOSURE Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhino- tracheitis. This invention also relates to methods for the production and use of the same.

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