A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 35/12 (2006.01) A61K 38/45 (2006.01) A61K 47/00 (2006.01) A61P 37/04 (2006.01) A61P 37/06 (2006.01) C12N 5/10 (2006.01) C12N 15/54 (2006.01) C12N 15/85 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2566267
The invention relates to a composition comprising: a stably integrating delivery vector; a modified mammalian thymidylate kinase (tmpk) wherein the modified mammalian tmpk increases phosphorylation of a prodrug relative to phosophorylation of the prodrug by wild-type human tmpk. The invention also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer.
Fowler Daniel H.
Lavie Arnon
Medin Jeffrey A.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Board Of Trustees Of The University Of Illinois
The Government Of The United States Of America As Represented By
University Health Network
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