Thymosin alpha 1 (ta1) peptides conjugates to polyethylene...

A - Human Necessities – 61 – K

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Details

A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C07K 14/575 (2006.01)

Patent

CA 2465874

A pharmaceutical composition includes a physiologically active conjugate including a Thymosin alpha 1 (TA1) peptide conjugated to a material which increases half-life of the TA1 peptide in serum of a patient when the conjugate is administered to a patient. The material may be a substantially non-antigenic polymer. In a method of the invention, the substantially non- antigenic polymer is conjugated to a TA1 peptide. Compositions according to the invention are administered to patients in need of immune stimulation.

Une composition pharmaceutique comprend un conjugué physiologiquement actif notamment un peptide thymosine alpha 1 (TA1) conjugué à une matière qui augmente la demi-vie du peptide TA1 dans le sérum d'un patient lorsque le conjugué est administré audit patient. Ladite matière peut être un polymère sensiblement non antigène. Selon un procédé de l'invention, ledit polymère sensiblement non antigène est conjugué à un peptide TA1. Selon l'invention, ces compositions sont administrées à des patients nécessitant une stimulation immunitaire.

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