Thyroid hormone receptor antagonists for cardiac and...

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 229/36 (2006.01) A61K 31/19 (2006.01) A61K 31/198 (2006.01) A61K 31/381 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61P 9/06 (2006.01) C07C 57/52 (2006.01) C07C 59/48 (2006.01) C07C 59/68 (2006.01) C07D 213/30 (2006.01) C07D 261/08 (2006.01) C07D 277/24 (2006.01) C07D 333/16 (2006.01)

Patent

CA 2446747

This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism and liver diseases.

L'invention concerne de nouveaux composés qui sont des ligands des récepteurs des hormones thyroïdiennes, de préférence, des antagonistes. L'invention a aussi pour objet des procédés pour utiliser ces composés pour traiter les troubles cardiaques et métaboliques, comme les arythmies du coeur, la thyrotoxicose, l'hyperthyroïdie sous-clinique et les maladies du foie.

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