Thyroid receptor ligands

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 251/60 (2006.01) A61K 31/192 (2006.01) A61K 31/40 (2006.01) A61K 31/4453 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) C07C 311/29 (2006.01) C07C 317/22 (2006.01) C07D 207/48 (2006.01) C07D 211/96 (2006.01)

Patent

CA 2741517

The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta (TR-Beta). Further, the present invention relates to processes of preparing such compounds, their tautomeric forms, novel intermediates involved in their synthesis, their pharmaceutically acceptable salts, methods for using such compounds and pharmaceutical compositions containing them.

La présente invention concerne de nouveaux composés de formule (I) générale. Ces composés sont des ligands des récepteurs thyroïdiens et sont de préférence sélectifs pour le récepteur bêta de l'hormone thyroïdienne (TR-bêta). En outre, la présente invention concerne des procédés de préparation de ces composés, leurs formes tautomères, de nouveaux intermédiaires impliqués dans leur synthèse, leurs sels pharmaceutiquement acceptables, des procédés pour utiliser ces composés et des compositions pharmaceutiques les contenant.

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