Thyrotropin-releasing hormone analogs in cns injury

Details Thyrotropin-releasing hormone analogs in cns injury Thyrotropin-releasing hormone analogs in cns injury

C - Chemistry, Metallurgy

07

K

167/103.46, 167/

C07K 5/097 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1323301

ABSTRACT OF THE DISCLOSURE The present invention involves compositions and the use thereof for treating traumatic or ischemic central nervous system injury in a patient suffering from ischemic or traumatic central nervous system injury by administering to said patient an effective amount of a thyrotropin-releasing hormone analog having preservation of terminal prolineamide. The thyrotropin-releasing hormone analog can be 6-methyl-5-oxo- thiomorpholinyl-3-carbonyl-histidyl-prolineamide, 4-(2-oxo- trimethylenimine)-carbonyl-histidyl-prolineamide, 4-(2-oxo- furan)-carbonyl-histidyl-prolineamide, an analog which modifies the pyroglutamyl moiety or a fluorine or iodine substituted histidyl analog.

568686

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