Thyroxin-binding proteins

Details Thyroxin-binding proteins Thyroxin-binding proteins

C - Chemistry, Metallurgy

12

N

C12N 15/14 (2006.01) A61K 38/38 (2006.01) C07H 21/04 (2006.01) C07K 14/765 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2186035

Modified forms of human serum albumin (HSA), wherein the arginine at position 218 is substituted by a less basic amino acid, show strong thyroxin-binding activity. These modified forms of HSA and fragments thereof are useful in binding thyroxin in standard assays for free thyroxin concentraton and in treating conditions characterized by higher-than-desired levels of free thyroxin in animal subjects.

On décrit des formes modifiées d'albumine sérique humaine où l'arginine en position 218 est substituée par un acide aminé moins basique, ces formes présentant une activité marquée de liaison avec la thyroxine. Ces albumines à formes modifiées et certains de leurs fragments permettent une liaison avec la thyroxine dans des titrages normalisés concernant la concentration en thyroxine libre et le traitement de troubles caractérisés par des niveaux trop élevés de thyroxine libre chez des animaux.

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