Tibolone in the treatment of complaints associated with the...

A - Human Necessities – 61 – K

Patent

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A61K 31/57 (2006.01) A61P 15/00 (2006.01) A61P 15/12 (2006.01)

Patent

CA 2472240

Disclosed is a treatment of estrogen-deficiency related complaints in females that exhibit these complaints while they are on treatment with a drug which prevents the synthesis of endogenous estrogen. Such drugs are, e.g., anti- cancer drugs such as aromatase inhibitors. The invention resides in the use of tibolone, which has an unexpectedly beneficial working in this particular patient group in that it does not stimulate breast, while preventing bone loss and relieving climacteric complaints in a patient group in which this is more difficult than in any other group due to the nature of the concomittant cancer treatment (no circulating estrogen making for a higher severity of the complaints, the lack of effect on the estrogen receptor making for an increased risk associated with estrogenic breast stimulation once estrogen- like compounds are administered.

Cette invention concerne un traitement d'affections liées à une carence oestrogénique qui frappent des femmes traitées par un médicament empêchant la synthèse d'oestrogène endogène. Ces médicaments sont notamment des anti-cancéreux tels que des inhibiteurs d'aromatase. L'invention concerne l'utilisation de tibolone, qui a une action bénéfique inattendue chez ce groupe particulier de patientes en ce qu'il ne stimule pas le sein, mais empêche une perte de masse osseuse et atténue les affections climatères, ceci dans un groupe de patientes chez lesquelles ces bienfaits sont plus difficiles à obtenir que chez d'autres compte tenu de la nature du traitement anti-cancéreux concomitant (pas de circulation d'oestrogènes accentuant la gravité des affections, absence d'effet sur le récepteur d'oestrogène entraînant une augmentation des risques associés à une stimulation oestrogénique du sein une fois administrés des composés de type oestrogène).

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