Tie-2 ligands, methods of making and uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) C12N 5/07 (2010.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) C07K 14/475 (2006.01) C07K 14/515 (2006.01) C07K 14/71 (2006.01) C07K 16/22 (2006.01) C07K 19/00 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2202028

The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

Cette invention se rapporte à une molécule d'acide nucléique isolée codant un ligand TIE-2 humain. Cette invention se rapporte en outre à un corps récepteur qui fixe spécifiquement un ligand TIE-2 humain, et à un anticorps qui fixe spécifiquement un ligand TIE-2 humain, ainsi qu'à un antagoniste de ligand TIE-2 humain. Cette invention se rapporte également à des compositions thérapeutiques et à un procédé pour bloquer la croissance des vaisseaux sanguins, à un procédé pour promouvoir la néovascularisation, à un procédé pour promouvoir la croissance ou la différenciation d'une cellule exprimant le récepteur de TIE-2, à un procédé pour bloquer la croissance ou la différenciation d'une cellule exprimant le récepteur de TIE-2, ainsi qu'à un procédé pour atténuer ou empêcher la croissance de tumeurs chez l'homme.

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