Tie-2 ligands, methods of making and uses thereof

Details Tie-2 ligands, methods of making and uses thereof Tie-2 ligands, methods of making and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) C07K 14/475 (2006.01) C07K 14/515 (2006.01) C07K 14/71 (2006.01) C07K 16/22 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2216963

The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

Molécule isolée d'acide nucléique codant pour un ligand du TIE-2 humain. L'invention porte en outre sur un corps récepteur fixant spécifiquement un ligand du TIE-2 humain, sur un anti-corps fixant spécifiquement un ligand du TIE-2 humain, sur un antagoniste du TIE-2 humain, sur des compositions thérapeutiques ainsi que sur des méthodes permettant de stopper le développement des vaisseaux sanguins, de promouvoir la néovascularisation, de promouvoir la croissance ou la différenciation d'une cellule exprimant le récepteur de TIE-2, de stopper la croissance ou la différenciation d'une cellule exprimant le récepteur de TIE-2 et d'atténuer ou de prévenir le développement d'une tumeur chez l'être humain.

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