C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/99 (2006.01) A61K 31/505 (2006.01) C07D 239/94 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 413/14 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2520323
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie- 2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
La présente invention a trait à des composés pour la modulation de l'activité enzymatique de la protéine kinase permettant la modulation d'activités cellulaires telles que la prolifération, la différenciation, l'apoptose, la migration et la chimio-invasion. Des composés de l'invention assurent l'inhibition, la régulation et/ou la modulation de kinases, notamment de Tie-2. L'invention a également trait à des procédés d'utilisation des composés et des compositions pharmaceutiques de ceux-ci pour le traitement de maladies et de conditions dépendantes de kinases.
Ibrahim Mohamed
Leahy James
Nuss John
Sangalang Joan C.
Schnepp Kevin
Bennett Jones Llp
Exelixis Inc.
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