Tie-2 modulators and methods of use

Details Tie-2 modulators and methods of use Tie-2 modulators and methods of use

A - Human Necessities

61

K

A61K 31/4439 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2520255

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie- 2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

L'invention concerne des procédés relatifs à la modulation d'activité enzymatique de protéine kinase, pour la modulation des activités cellulaires du type prolifération, difféenciation, mort cellulaire programmée, migration et chimioinvasion. On décrit des composés inhibant, régulant et/ou modulant les kinases, en particulier de type Tie-2. L'invention concerne également des procédés relatifs à l'utilisation de ces composés, et de compositions pharmaceutiques les renfermant, pour le traitement des maladies et des affections qui dépendent de la kinase.

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