Tie complex binding proteins

Details Tie complex binding proteins Tie complex binding proteins

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2576886

Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.

Tie1 et Tie2 sont des protéines tyrosine kinases réceptrices comportant un domaine transmembranaire. Tie1 et Tie2 sont présents sur des cellules endothéliales. La présente invention a trait à des agents, tels que des anticorps, de liaison à Tie1, Tie2, et à l'angiopoiétine, comprenant ceux qui sont inhibiteurs de l'activité de cellules endothéliales et de l'angiogenèse. Les agents peuvent être utilisés pour le traitement de troubles associés à l'angiogenèse.

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