Tie1-binding ligands

Details Tie1-binding ligands Tie1-binding ligands

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2535171

Tiel is a receptor tyrosine kinase protein that includes a transmembrane domain. Tiel is present on endothelial cells. This disclosure described antibodies that bind to Tiel, including ones that inhibit endothelial cell activity.

L'invention porte sur le Tie 1, récepteur de la protéine tyrosine kinase, qui comporte un domaine transmembranaire et qui est présent dans les cellules endothéliales, et sur des anticorps se fixant au Tie 1, dont certains sont des inhibiteurs de l'activité des cellules endothéliales.

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