C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2616778
Compounds and components including sequences for mucosal epithelial transport of an active agent are given. Tight junction modulating peptide components are described for use in transport and delivery. Permeability can be enhanced with reversibility. Compounds and components for enhanced delivery may be peptide or protein variants, conjugates, or other analog types and structures.
L'invention concerne des composés et des composantes comprenant des séquences pour le transport épithélial muqueux d'un agent actif. Ces composantes peptidiques modulant la jonction serrée sont destinées à être utilisées dans le transport et le dégagement. La perméabilité peut être augmentée avec la réversibilité. L'invention concerne également des composés et composantes pour un dégagement amélioré, lesquels peuvent être des variants peptidiques ou protéiques, des conjugués, ou d'autres types et structures analogues.
Costantino Henry R.
Cui Kunyuan
Houston Michael E.
Johnson Paul Hickok
Lamharzi Najib
Borden Ladner Gervais Llp
Marina Biotech Inc.
Nastech Pharmaceutical Company Inc.
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