Tighter-binding c-peptide inhibitors of hiv-1 entry

Details Tighter-binding c-peptide inhibitors of hiv-1 entry Tighter-binding c-peptide inhibitors of hiv-1 entry

C - Chemistry, Metallurgy

07

K

C07K 14/16 (2006.01) A61K 38/16 (2006.01)

Patent

CA 2680899

The invention provides compositions and methods for the treatment of HIV infection, inhibition against drug-resistant strains of HIV-1 and methods of enhancing the anti-HIV potency of peptide inhibitors against drug-resistant strains of HIV-1. In particular, oligomeric C-peptide inhibitors for inhibiting HIV entry into host cells are disclosed.

Cette invention se rapporte à des compositions et des procédés permettant de traiter l'infection à VIH et d'inhiber les souches du VIH-1 pharmacorésistantes ; l'invention concerne également des procédés permettant de stimuler la puissance anti-VIH d'inhibiteurs peptidiques contre les souches du VIH-1 pharmacorésistantes. L'invention concerne en particulier des inhibiteurs à base de peptide C oligomère qui inhibent la pénétration du VIH dans les cellules hôtes.

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