Tissue adhesive sealant

A - Human Necessities – 61 – L

Patent

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Details

A61L 24/10 (2006.01) A61K 8/64 (2006.01) A61Q 19/08 (2006.01) C09J 11/06 (2006.01) C09J 189/00 (2006.01) C12N 5/071 (2010.01) C07K 1/10 (2006.01)

Patent

CA 2533551

A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.

L'invention concerne un agent de scellement adhésif tissulaire comprenant une protéine réticulable dans une solution qui, lorsqu'elle est combinée avec une solution d'agent de réticulation comprenant un aldéhyde et une espèce contenant de l'aminoacide, ladite espèce réagissant avec l'aldéhyde, réticule pour former un joint. L'agent de scellement est bien adapté pour lier un tissu, seul ou en combinaison avec une pastille. Le rapport entre l'aldéhyde et l'espèce contenant l'aminoacide est compris entre 20 :1 et 1 :1 sur une base molaire, fraction aldéhyde:sous-unité aminoacide ou peptide. Des joints particulièrement résistants sont obtenus lorsque la protéine et l'agent de réticulation se trouvent dans un rapport molaire compris entre 15 :1 et 1 :1.

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