Tissue adhesive using synthetic cross-linking

C - Chemistry – Metallurgy – 08 – L

Patent

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Details

C08L 89/00 (2006.01) A61L 24/10 (2006.01) C07K 14/00 (2006.01) C08G 69/10 (2006.01) C08G 69/48 (2006.01) C08H 1/00 (2006.01) C08L 77/00 (2006.01)

Patent

CA 2219020

Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for cross- linking to provide strongly adherent tissue adhesives and sealants. Particularly, block copolymers of elastin and fibroin are employed having lysine substitutions in spaced apart units, where the amino group can be cross- linked using difunctional cross-linking agents.

On utilise des polymères protéiniques à unités répétitives provenant de protéines structurales d'origine naturelle comme squelettes pour des fonctionnalités de réticulation afin d'obtenir des colles et produits d'obturation pour tissus à fort pouvoir adhésif. En particulier, on utilise des copolymères séquencés d'élastine et de fibroïne à substitutions par la lysine dans des unités espacées, dans lesquels le groupe amino peut être réticulé à l'aide d'agents de réticulation bifonctionnels.

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