Tissue-and serum-derived glycoproteins and methods of their use

G - Physics – 01 – N

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G01N 33/574 (2006.01)

Patent

CA 2625403

The present invention is directed generally to tissue-derived glycoproteins and glycosites detectable in plasma via mass spectrometric analysis of glycoproteins from both tissues and blood. The invention also provides methods for identifying tissue-derived glycoproteins and glycosites in plasma, panels of detection reagents for detecting same, as well methods for detecting disease using such panels. The invention further provides a database of tissue- derived glycoproteins and glycosites detectable in plasma.

La présente invention porte, de manière générale, sur des glycoprotéines et glycosites dérivés de tissus et pouvant être détectés dans le plasma par analyse spectrométrique de masse des glycoprotéines provenant à la fois des tissus et du sang. L'invention porte également sur des méthodes d'identification des glycoprotéines et des glycosites dérivés de tissus dans le plasma, sur des panels de réactifs de détection pour les détecter, ainsi que sur des méthodes de détection de maladies utilisant ces panels. L'invention porte également sur une base de données de glycoprotéines et de glycosites dérivés de tissus et pouvant être détectés dans le plasma.

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