C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) C07K 1/22 (2006.01) C07K 1/30 (2006.01) C07K 14/495 (2006.01) C12N 15/10 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2084992
2084992 9200318 PCTABS00010 The present invention provides methods for producing and purifying proteins comprising TGF-.beta.3 precursor, pro region of the TGF-.beta.3 precursor and mature TGF-.beta.3. Moreover, this invention also provides methods for producing and purifying novel homodimeric proteins with enhanced production and heightened therapeutic utility which comprises mutations, signal peptide deletions, and protease cleavage site substitutions.
Dijke Peter Ten
Foulkes J. Gordon
Haley John D.
Iwata Kenneth K.
Gowling Lafleur Henderson Llp
Osi Pharmaceuticals Inc.
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