Tissue-derived tumor growth inhibitors, methods for...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/18 (2006.01) C07K 1/22 (2006.01) C07K 1/30 (2006.01) C07K 14/495 (2006.01) C12N 15/10 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2084992

2084992 9200318 PCTABS00010 The present invention provides methods for producing and purifying proteins comprising TGF-.beta.3 precursor, pro region of the TGF-.beta.3 precursor and mature TGF-.beta.3. Moreover, this invention also provides methods for producing and purifying novel homodimeric proteins with enhanced production and heightened therapeutic utility which comprises mutations, signal peptide deletions, and protease cleavage site substitutions.

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