Tissue-engineered vascular structures

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/071 (2010.01) A61F 2/06 (2006.01) A61F 2/36 (2006.01) A61L 27/38 (2006.01) A61L 33/18 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2426819

The present invention is directed to novel, less invasive and improved methods of tissue-engineering of constructs that require an endothelial surface such as blood vessels and heart valves. The constructs of the present invention possess long-term patency. The method of the present invention is particularly suited for making small diameter vessels to replace clogged or damaged coronary blood vessels, for making trileaflet heart valve conduits to replace damaged or malformed pulmonic and aortic valves, and for other vascular structures that require an endothelial surface.

L'invention concerne de nouveaux procédés améliorés et peu vulnérants de synthèse de tissus nécessitant une surface endothéliale, tels que des vaisseaux sanguins et des valvules cardiaques. Ces tissus de synthèse possèdent une perméabilité à long terme. Le procédé est particulièrement approprié dans la fabrication de vaisseaux de faible diamètre destinés à remplacer des vaisseaux sanguins coronaires obstrués ou endommagés, de conduits de valvule cardiaque à trois lames destinés à remplacer des valvules aortiques et pulmonaires présentant une lésion ou une malformation, ainsi que d'autres structures vasculaires nécessitant une surface endothéliale.

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