Tissue factor pathway inhibitor-3

Details Tissue factor pathway inhibitor-3 Tissue factor pathway inhibitor-3

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/57 (2006.01) A61K 39/395 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2279345

The present invention relates to a novel TFPI-3 protein which is a member of the tissue factor protease inhibitor family. In particular, isolated nucleic acid molecules are provided encoding human TFPI-3 proteins. TFPI-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TFPI-3 activity. Also provided are diagnostic methods for detecting hemostasis system-related disorders and therapeutic methods for treating hemostatis system-related disorders.

L'invention concerne une nouvelle protéine TFPI-3 qui fait partie de la famille des inhibiteurs des protéases de la thromboplastine tissulaire. Elle concerne notamment des molécules d'acide nucléique isolées codant les protéines TFPI-3 humaines. Elle concerne aussi des polypeptides TFPI-3, des vecteurs, des cellules hôtes et des méthodes de recombinaison permettant de les produire. Elle concerne également des méthodes de criblage permettant d'identifier les agonistes et antagonistes de l'activité TFPI-3. Elle concerne enfin des méthodes diagnostiques permettant de détecter les troubles en rapport avec le système hémostatique et des méthodes thérapeutiques permettant de traiter lesdits troubles.

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