Tissue factor production inhibitor

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/216 (2006.01) A61K 31/405 (2006.01) A61K 31/517 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2572872

A pharmaceutical having the potency of inhibiting the production of tissue factors, which pharmaceutical comprises an LXR ligand as an active ingredient. There is provided a pharmaceutical for the treatment and/or prevention of vascular re-stenosis encountered after angioplasty, endarterectomy, percutaneous coronary angioplasty (PTCA) or stent placement, or for the treatment and/or prevention of blood coagulation disorder, diseases induced by platelet aggregation including stable or unstable angina, disorders of cardiovascular and cerebrovascular systems including thromboembolism induced by diabetes, re-thrombosis encountered after thrombolysis, brain ischaemia seizure, infarction, apoplexy, dementia resulting from ischemia, peripheral arterial disease, thromboembolism encountered during the use of aortocoronary bypass, glomerulosclerosis, kidney embolism, tumor or cancer metastasis, which pharmaceutical comprises an LXR ligand as an active ingredient.

Un produit pharmaceutique ayant la possibilité d~inhiber la production de facteurs tissulaires, lequel produit pharmaceutique comprend un ligand LXR comme ingrédient actif. On propose un produit pharmaceutique pour le traitement et/ou la prévention de la re-sténose vasculaire rencontrée après une angioplastie, une endartériectomie, une angioplastie coronaire percutanée (PTCA) ou le positionnement d~un stent, ou pour le traitement et/ou la prévention du trouble de la coagulation sanguine, des maladies induites par l~agrégation plaquettaire comprenant l~angor stable ou instable, les troubles des systèmes cardiovasculaire et cérébrovasculaire comprenant la thrombo-embolie induite par le diabète, la re-thrombose rencontrée après une thrombolyse, une attaque d~ischémie cérébrale, un infarctus, une apoplexie, une démence résultant d~une ischémie, une maladie artérielle périphérique, une thrombo-embolie rencontrée lors de l~utilisation d~un pontage coronarien, une glomérulosclérose, une embolie rénale, une métastase tumorale ou cancéreuse, lequel produit pharmaceutique comprend un ligand LXR comme ingrédient actif.

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