Tissue factor protein variants with increased affinity for...

Details Tissue factor protein variants with increased affinity for... Tissue factor protein variants with increased affinity for...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/36 (2006.01) C07K 14/705 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2335274

The invention provides amino acid sequence variants of tissue factor protein. The tissue factor protein variants have a greater affinity for Factor VII/VIIa than wild-type counterparts. The invention also provides pharmaceutical compositions comprising the novel compositions as well as their use in diagnostic, therapeutic, and prophylactic methods.

La présente invention concerne des variantes de séquence d'acides aminés de protéines de facteur tissulaire. Ces variantes de protéines de facteur tissulaire présentent une affinité accrue pour le Facteur VII/VIIa que les équivalents de type sauvage. L'invention concerne également des compositions pharmaceutiques comprenant les compositions de l'invention. L'invention concerne enfin leur utilisation pour des procédures diagnostiques, thérapeutiques et prophylactiques.

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