A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) A61K 31/00 (2006.01) A61P 9/00 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2693921
This invention relates to methods of treating Alzheimer's disease or symptoms thereof, and amnesic mild cognitive impairment or symptoms thereof. Methods of the invention include administering a therapeutically effective amount of tissue kallikrein, variants or active fragments thereof. The invention further relates to uses of tissue kallikrein or a variant or active fragment thereof for the digesting or cleaving amyloid and the treatment of conditions benefiting from the digestion or cleavage of amyloid. The invention further relates to pharmaceutical compositions comprising a therapeutically effective amount of tissue kallikrein, variants or active fragments thereof formulated for oral or intranasal administration.
ABSTRACT La présente invention concerne des procédés de traitement de la maladie d'Alzheimer ou de ses symptômes, ainsi que des troubles cognitifs légers amnésiques ou leurs symptômes. Les procédés de l'invention comprennent l'administration d'une quantité thérapeutiquement efficace de kallikréine tissulaire, de ses variantes ou de fragments actifs. L'invention concerne également l'utilisation de kallikréine tissulaire, d'une variante ou bien d'un fragment actif pour digérer et cliver l'amyloïde, ainsi que le traitement des conditions bénéficiant de la digestion et du clivage de l'amyloïde. L'invention concerne enfin des compositions pharmaceutiques qui comprennent une quantité thérapeutiquement efficace de kallikréine tissulaire, de ses variantes ou de fragments actifs formulés pour une administration orale ou intra-nasale.
Genesys Venture Inc.
Ridout & Maybee Llp
Sanomune Inc.
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