Tissue matrix system

Details Tissue matrix system Tissue matrix system

A - Human Necessities

61

K

A61K 9/14 (2006.01)

Patent

CA 2570521

The present application discloses matrix compositions to support the repair of tissue defects such as an osteochondral injury. A matrix described herein comprises a polyester polymer entangled with a polysaccharide polymer. Also disclosed are methods of preparing a matrix, and methods of using a matrix in the repair of tissue. In certain configurations, a matrix can comprise a polyester cross-linked with a polysaccharide, which can be an oxidized polysaccharide. In some configurations, a matrix can further comprise one or more additional components, such as a growth factor.

L'invention concerne des compositions matricielles destinées à favoriser la réparation de défauts tissulaires, par exemple une lésion ostéochrondrale. La matrice, selon l'invention, comprend un polymère polyester enchevêtré avec un polymère de polysaccharide. L'invention concerne également des procédés permettant de préparer une matrice, et des procédés d'utilisation d'une matrice lors de la réparation tissulaire. Dans certaines configurations, une matrice peut comprendre un polyester réticulé avec un polysaccharide, qui peut être un polysaccharide oxydé. Dans certaines autres configurations, une matrice peut également comprendre un ou plusieurs composants, par exemple un facteur de croissance.

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