C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/39.1, 195/1.
C12N 15/64 (2006.01) C12N 1/00 (2006.01) C12N 9/68 (2006.01) C12N 9/72 (2006.01) C12N 15/58 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2008264
ABSTRACT The plasminogen activator is a N-terminal peptide of plasminogen linked to t-PA. Tile DNA encoding amino acid sequence of the t-PA is also disclosed as well as the expression vector comprising the DNA. Also disclosed is a host cell transformed with such expression vector. A process of producing the plasminogen actuator as well as the pharma- ceutical composition containing same are described. The tissue plasminogen activator has a strong activity for converting plasminogen into plasmin that degrades the fibrin network of blood clot to form soluble products and therefore is useful as a thrombolytic agent.
Kusunoki Chihiro
Niwa Mineo
Otsuka Kazuyuki
Satoh Susumu
Suzuki Shingo
Fujisawa Pharmaceutical Co. Ltd.
Swabey Ogilvy Renault
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