Tissue plasminogen activator having fibrin specific properties

Details Tissue plasminogen activator having fibrin specific properties Tissue plasminogen activator having fibrin specific properties

C - Chemistry, Metallurgy

12

N

C12N 15/58 (2006.01) A61K 38/49 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2075901

A tissue plasminogen activator (t-PA) variant is prepared that has an amino acid deletion at positions 466 to 470 of the corresponding wild-type t-PA. This alteration renders the variant fibrin (and plasma clot) specific as compared to the correspond- ing wild-type t-PA. DNA sequences can be prepared that encode the variant, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variant may be used in a pharmaceutical prepara- tion to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.

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