Tissue plasminogen activator variant uses

Details Tissue plasminogen activator variant uses Tissue plasminogen activator variant uses

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61M 25/00 (2006.01)

Patent

CA 2668347

A method is disclosed for using tenecteplase to restore function in dysfunctional hemodialysis catheters, which have a blood flow rate of less than 300 mL/minute. Kits are also provided with instructions to direct the user to administer tenecteplase in a total dose of about 3 to 4 mg locally into all catheter lumens and allow the tenecteplase to dwell in the catheter for from about one hour to about 72 hours.

L'invention concerne un procédé pour utiliser une ténectéplase pour rétablir la fonction de cathéters d'hémodialyse dysfonctionnels, qui ont un débit de sang inférieur à 300 mL/minute. Des trousses sont également proposées avec des instructions pour amener l'utilisateur à administrer de la ténectéplase à une dose totale d'environ 3 à 4 mg localement dans toutes les lumières du cathéter et à laisser la ténectéplase gonfler dans le cathéter pendant environ une heure à environ 72 heures.

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