Tissue plasminogen activator variants with decreased clearance

Details Tissue plasminogen activator variants with decreased clearance Tissue plasminogen activator variants with decreased clearance

C - Chemistry, Metallurgy

12

N

C12N 15/58 (2006.01) A61K 38/49 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 9/72 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2086835

Biologically active tissue plasminog- en activator (t-PA) variants with decreased clearance as compared to wild-type t-PA are prepared, including variants that have one or more amino acid-alterations in at least the kringle-1 and/or kringle-2 domain(s) of the molecule. DNA sequences can be pre- pared that encode the variants, as well as ex- pression vectors incorporating the DNA se- quences and host cells transformed with the expression vectors. The variants may be used in pharmaceutical preparations to treat a vascular disease or condition, or to pre- vent fibrin deposition or adhesion formation or reformation in mammals.

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