Tissue protective cytokine receptor complex, assays for...

G - Physics – 01 – N

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G01N 33/50 (2006.01) C12Q 1/02 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2523578

The present invention is directed methods for identifying compounds that have a tissue protective activity using a heteromultimer receptor complex that mediates the tissue protective activities. The complex consists of at least one EPO-R in complex with at least one .beta.c Receptor. These compounds used in the assays to identify tissue protective compounds include, but are not limited to, small molecules and biologics. The compounds identified using these assays can be used to treat or prevent various diseases, disorders, or conditions of the central and peripheral nervous systems as well as those of other erythropoietin-responsive or excitable cells, tissues, and organs.

L'invention concerne des procédés d'identification de composés présentant une activité protectrice de tissus, au moyen d'un complexe récepteur hétéromultimère qui médie les activités protectrices de tissus. Ce complexe consiste en au moins un EPO-R dans le complexe avec au moins un récepteur .beta.c. Ces composés utilisés dans les dosages pour identifier des composés protecteurs de tissus comprennent, entre autres, des petites molécules et des produits biologiques. Les composés identifiés au moyen de ces dosages peuvent servir à traiter ou prévenir plusieurs maladies, troubles, ou conditions du système nerveux central et périphérique ainsi que ceux d'autres cellules, tissus ou organes sensibles à l'érythropoïétine ou pouvant être excités.

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