Tissue reactive compounds and compositions and uses thereof

Details Tissue reactive compounds and compositions and uses thereof Tissue reactive compounds and compositions and uses thereof

A - Human Necessities

61

K

A61K 31/787 (2006.01) A61K 31/765 (2006.01) A61K 31/785 (2006.01) A61K 31/795 (2006.01) A61K 45/00 (2006.01) A61P 41/00 (2006.01) A61K 31/337 (2006.01) A61K 31/365 (2006.01) A61K 31/475 (2006.01)

Patent

CA 2511486

A composition comprising a synthetic polymer, optionally in the presence of a drug, where the polymer comprises multiple activated groups. The multiple activated groups are reactive with functinality present on animal tissue, so that upon administration of the polymer to the tissue, the polymer binds to the tissue. Alternatively, the multiple activated groups are reactive with functionality present on a non-living surface, where the polymer binds to this surface to, e.g., increase the lubricity of the surface. When drug is present in the composition, the drug is then delivered to the site of polymer attachment.

La présente invention se rapporte à une composition comportant un polymère synthétique, éventuellement associé à un médicament, ledit polymère comprenant de multiples groupes activés. Les multiples groupes activés réagissent à une fonctionnalité présente sur un tissu animal, de sorte que lors de l'administration du polymère au tissu, ledit polymère se lie au tissu. Les multiples groupes activés peuvent également réagir à une fonctionnalité présente sur une surface non vivante, ledit polymère se liant à la surface de manière à, par exemple, accroître le pouvoir lubrifiant de ladite surface. Lorsqu'un médicament est présent dans la composition, le médicament est alors délivré sur le site de fixation du polymère.

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