C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 31/711 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) C12N 9/00 (2006.01) C12N 9/22 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2274584
The invention provides compositions comprising the tissue specific and target RNA-specific ribozyme(s) in either a viral delivery system or a biologic liposome preparation, wherein the viral delivery system or a biologic liposome comprises a pathogen-specific promotor upstream from a sequence encoding a triple ribozyme comprising a) a 5' autocatalytically cleaving ribozyme sequence, b) a catalytic ribozyme comprising a target RNA-specific binding site and c) a 3' autocatalytically cleaving ribozyme sequence. The invention also provides methods of treating and/or preventing bacterial infections by administering the compositions of the invention.
L'invention porte sur des compositions comprenant le ou les ribozymes spécifiques de tissus, et spécifiques d'un ARN cible, contenus soit dans un système de distribution viral, soit dans une préparation abiologique de liposomes. Le système de distribution viral ou le liposome abiologique comprennent un promoteur spécifique d'un pathogène en amont de la séquence codant pour un ribozyme triple comportant: (a) une séquence de ribozyme en 5' à clivage autocatalytique; (b) un ribozyme catalytique comportant un site de fixation spécifique d'un ARN cible, et (c) une séquence de ribozyme en 3' à clivage autocatalytique. L'invention porte également sur des méthodes de traitement et/ou de prévention d'infections bactériennes par administration des compositions de l'invention.
Clawson Gary A.
Dolan Joseph W.
London Steven D.
May Harold D.
Norris James S.
Medical University Of South Carolina
Osler Hoskin & Harcourt Llp
Penn State Research Foundation
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