Tissue specific expression of antibodies in chickens

Details Tissue specific expression of antibodies in chickens Tissue specific expression of antibodies in chickens

C - Chemistry, Metallurgy

07

K

C07K 16/02 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2597837

Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are preferably expressed in the oviduct for collection in the egg. Tissue specificity is provided by selecting the content of the transgene accordingly. Birds whose genome is comprised of trangene- derived exogenous antibody-encoding DNA express exogenous antibodies having desirable chemical properties with increased therapeutic utility compared to antibodies derived from bacterial expression systems.

L'invention concerne des transgènes codant pour des anticorps exogènes qui sont intégrés de manière stable dans des cellules donneuses et sont présents dans le tissu somatique d'oiseaux chimères. Lesdits transgènes codent pour des anticorps exogènes et sont, de préférence, exprimés dans l'oviducte pour être concentrés dans l'oeuf. La spécificité tissulaire est fournie par sélection du contenu du transgène correspondant. Les oiseaux dont le génome est contient un AND codant pour un anticorps exogène dérivé d'un transgène expriment des anticorps exogènes dotés de propriétés chimiques désirables à utilité thérapeutique accrue par rapport aux anticorps dérivés des systèmes d'expression bactériens.

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