Tissue specific hypoxia regulated therapeutic constructs

Details Tissue specific hypoxia regulated therapeutic constructs Tissue specific hypoxia regulated therapeutic constructs

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 9/02 (2006.01) C12N 15/12 (2006.01) C12N 15/53 (2006.01) C12N 15/67 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2208599

Methods and compositions relating to chimeric genes containing (i) a tissue- specific promoter and (ii) a hypoxia response enhancer element, both of which are operably linked to a selected gene, such as a reporter gene, therapeutic gene (e.g., bcl-2, NOS, catalase and SOD), or deleterious gene are disclosed. Expression of the selected gene is enhanced in the target tissue under hypoxic conditions, such as conditions encountered during episodes of ischemia and reperfusion. The methods and compositions may be used as therapeutics and/or diagnostics.

On décrit des procédés et des compositons concernant des gènes chimériques. Ces compositions comprennent: 1) un promoteur spécifique d'un tissu et 2) un élément adjuvant de réponse à l'hypoxie, les deux étant opérationnellement liés à un gène déterminé tel qu'un gène reporter, un gène thérapeutique (leucémie/lymphome 2 de lymphocyte B, synthase d'oxyde nitrique, catalase et superoxyde dismutase, par exemple) ou un gène délétère. L'expression du gène sélectionné est favorisée dans un tissu cible, en présence de conditions hypoxiques telles que celles existant lors d'épisodes d'ischémie ou de reperfusion. Ces procédés et compositions servent à la thérapie et au diagnostic.

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