Tissue specific transcriptional regulatory element

Details Tissue specific transcriptional regulatory element Tissue specific transcriptional regulatory element

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2143336

The present invention therefore provides a transcriptional regulatory element which is capable of directing expression of a gene specifically in cells of the endothelial lineage. Preferably, the transcriptional regulatory element comprises the initiation cod- on and the untranslated sequence of tek, a protein tyrosine kinase expressed during murine cardiogenesis and homologues there- of including the human tek gene. The transcriptional regulatory element may be used to target expression of a gene in cells of the endothelial lineage.

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